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pentobarbital will reduce the extent or effect of bosentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.pentobarbital increases toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. CYP3A4 inducers may perhaps boost the metabolism of ifosfamide to its Energetic